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Updated: Oct 20, 2025

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利用E3连接酶KEAP1进行向蛋白质降解

Jieli Wei1, Fanye Meng1, Kwang-Su Park1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

Journal of the American Chemical Society
|September 14, 2021
PubMed
概括

这项研究引入了一种使用KEAP1 E3链酶进行向蛋白质降解的新型蛋白质分解向基因组 (PROTAC). 新的PROTAC,MS83,有效降解BRD4和BRD3蛋白质,提高耐用性和抗增殖活性.

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