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Updated: May 2, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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一种工程 IL-2 部分激动剂促进 CD8+ T 干细胞

Fei Mo1, Zhiya Yu2, Peng Li1

  • 1Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Nature
|September 16, 2021
PubMed
概括

一种工程化细胞因子H9T扩大CD8+T细胞用于癌症免疫疗法,而不会导致终端分化. 这种方法保持了类似干细胞的状态,在临床前模型中增强了抗瘤活性.

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