关于"异常类型的免疫力导致对粘膜真菌感染的易感性"的评论
Anne Puel1,2,3,4, Jean-Laurent Casanova1,2,3,4
1Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
概括
1型自身免疫多分泌综合征的慢性粘膜皮质候群不仅仅是由于干扰素的过度使用. 中和17型细胞因子的自身抗体也起着重要作用,挑战了最近的发现.
科学领域:
- 免疫学
- 内分泌学
- 遗传学
背景情况:
- 慢性粘膜皮质候群与AIRE (自身免疫调节器) 和自身免疫多分泌综合征1型 (APS-1) 的先天性错误有关.
- 之前的研究表明,针对IN-17 (IL-17) 细胞因子的自身抗体在APS-1的候群病变中起作用.
- 最近的发现表明过度的干扰素- (IFN-γ) 生产是主要原因,质疑IL-17中和的作用.
研究的目的:
- 对Break等人提出的说法进行批判性评估. 关于 APS-1 中慢性粘膜皮质候群病的病因.
- 重新检查支持IFN-γ和IL-17中和自抗体在疾病发病中的作用的证据.
- 将最近的发现与超过35年的现场研究所获得的知识相协调.
主要方法:
- 对Break等人提出的数据进行了批判性分析. 在研究.
- 对APS-1和角膜病的35年研究现有文献和历史数据的审查.
- 对涉及IFN-γ和IL-17中和的拟议机制的比较评估.
主要成果:
- 根据Break等人提供的数据. 不能肯定地支持他们的说法,即过度的IFN-γ产量是APS-1候群病的唯一原因.
- 建议排除中和IL-17细胞因子的自身抗体没有充分的支持,并且与已知的发现相矛盾.
- 这项研究强调了最近的说法与长期存在的证据之间的不一致性.
结论:
- 在APS-1中,慢性粘膜皮质候群的发病可能涉及复杂的因子相互作用,包括IFN-γ和IL-17通路.
- 自身抗体中和IL-17细胞因子的作用仍然是一个不可忽视的重要因素.
- 需要进行进一步的研究,以充分阐明APS-1中白病的潜在机制,并整合最近和历史数据.
相关概念视频
Factors Affecting the Risk of Infection
12.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.8K
Cell-mediated Immune Responses
76.0K
Overview
76.0K
Fungal Phylum Microsporidia
183
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
183
Pulmonary Tuberculosis I
419
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
419
Antigens Involved in Adaptive Immunity
794
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
794
T Cell Types and Functions
1.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K


