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Updated: Oct 19, 2025

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

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3'UTR变异的全基因组功能查揭示了人类疾病和演变的因果变异

Dustin Griesemer1, James R Xue2, Steven K Reilly2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA 02143, USA; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA 02115, USA; Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Cell
|September 17, 2021
PubMed
概括

我们开发了一种新的测定方法 (MPRAu) 来研究3'未翻译区域 (3'UTR) 变异,确定了与人类特征和疾病相关的数百种因果变异. 这种方法揭示了miRNA调节和进化适应等机制.

关键词:
3'UTR 时间在GWAS在MPRA一个进化功能性基因组学遗传变体监管基因组学

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