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Updated: Oct 19, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
10:13

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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抗原主导层次在瘤中形成TCF1+ CD8 T细胞原型

Megan L Burger1, Amanda M Cruz2, Grace E Crossland1

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|September 17, 2021
PubMed
概括

瘤新抗原反应主要是由稳定的MHC结合剂. 一个对较弱抗原有反应的T细胞子集,虽然最初对免疫疗法有希望,但被发现功能失调且对免疫检查点阻断无反应.

关键词:
CCR6 其他CD8 T 细胞一个 TCF其他:检查点封锁免疫主导性肺癌 肺癌新抗原疫苗的使用

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