在B期心力衰竭患者中,一年的炼训练逆转了异常的左心室肌肉硬
Michinari Hieda1,2,3, Satyam Sarma1,2, Christopher M Hearon1,2
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (M.H., S.S., C.M.H., J.P.M., K.A.D., M.S., D.P., S.L., M.M., B.D.L.).
Circulation
|September 20, 2021
概括
高强度运动可显著降低左心室 (LV) 肌肉硬度的患者与LV增大和心脏生物标志物. 这表明运动可以预防未来的心力衰竭,
科学领域:
- 心脏病学
- 运动生理学
- 心脏衰竭的研究
背景情况:
- 中年患者左心室缩和心脏生物标志物升高会增加心力衰竭的风险.
- 已知长时间的运动可以在健康的老年人中逆转 LV 硬化,但其对高风险患者的影响尚不清楚.
研究的目的:
- 调查1年长时间的运动是否能使LV心肌硬度正常化,这些患者患有LV心肌缩和心脏生物标志物升高.
- 评估运动对高风险HFpEF患者心脏功能的影响.
主要方法:
- 一项前性随机对照试验,涉及46名患有 LV 缩和心脏生物标志物升高的患者.
- 患者被分配到一年的高强度运动训练 (n=30) 或注意力控制组 (n=16).
- 在预加载操作过程中使用右心导管和3D回声造影来确定LV心肌硬度,并从LV末端透气压力-体积关系计算硬度.
主要成果:
- 与对照人群相比,一年的运动训练显著增加了心脏呼吸能力 (VO2最大值) 21%.
- 与对照组相比,运动训练显著降低了心肌硬度 (基线为0. 062±0. 020至0. 031±0. 009,P=0. 001).
- 在对照组中没有观察到VO2max或LV心肌硬度的显著变化.
结论:
- 一年高强度运动有效地降低了LV心肌硬度,这些患者患有LV缩和心脏生物标志物升高.
- 在这种高危人群中,运动训练可能是预防心力衰竭的保护策略.
- 临床试验.gov 标识:NCT03476785.
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