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Updated: Oct 19, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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高流动性组盒1 (HMGB1) 的O-GlcNAcylation改变其DNA结合和DNA损伤处理活动

Aaron T Balana, Anirban Mukherjee1, Harsh Nagpal2

  • 1Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, Texas 78723, United States.

Journal of the American Chemical Society
|September 21, 2021
PubMed
概括

蛋白质O-GlcNAcylation改变了HMGB1,影响了其DNA结合和修复功能. 这种糖修饰增强了HMGB1对受损DNA的寡合化,并损害了DNA修复,可能将O- GlcNAc与癌症突变联系起来.

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