Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Olfaction01:25

Olfaction

46.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
46.2K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

1.5K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
1.5K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

1.3K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
1.3K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

654
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
654
Association Areas of the Cortex01:21

Association Areas of the Cortex

6.9K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
6.9K
Associative Learning01:27

Associative Learning

686
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
686

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Early life Oxytocin treatment Attenuates Seizure Susceptibility in Male, but not Female, <i>Fmr1</i>-KO Mice.

bioRxiv : the preprint server for biology·2026
Same author

Unilateral damage to the entopeduncular nucleus causes dysfunction in skilled forelimb movement and hinders recovery in rats.

Neuroscience letters·2026
Same author

Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer's disease.

Nature neuroscience·2026
Same author

Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: Oct 19, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K

多巴胺促进体内皮层的关联记忆编码

Jason Y Lee1, Heechul Jun1, Shogo Soma1,2

  • 1Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, USA.

Nature
|September 23, 2021
PubMed
概括

侧腔内皮层 (LEC) 的多巴胺信号通过帮助风扇细胞编码新的提示奖励关联来指导学习. 这种由多巴胺驱动的过程对于将新记忆纳入认知地图至关重要.

更多相关视频

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

4.0K
In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

9.3K

相关实验视频

Last Updated: Oct 19, 2025

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K
Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

4.0K
In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster
06:35

In Vivo Optical Calcium Imaging of Learning-Induced Synaptic Plasticity in Drosophila melanogaster

Published on: October 8, 2019

9.3K

科学领域:

  • 神经科学
  • 认知科学
  • 学习和记忆

背景情况:

  • 状体中的多巴胺是强化学习的关键.
  • 多巴胺奖励信号对内腔-海马回路的影响尚不清楚.
  • 这种电路对学习和记忆至关重要.

研究的目的:

  • 为了研究多巴胺如何影响内海马回路.
  • 确定多巴胺在侧腔内皮层 (LEC) 编码提示奖励关联中的作用.

主要方法:

  • 在小鼠中进行细胞类型特定的电生理记录.
  • 对LEC风扇细胞的光遗传抑制.
  • 用光纤测量多巴胺信号.

主要成果:

  • 多巴胺信号控制LEC层2a风扇细胞中的提示奖励规则的编码.
  • LEC 风扇细胞将新学习的奖励线索与先前学习的奖励线索组合在一起.
  • 抑制风扇细胞会影响新学习,但不会影响记忆.
  • 在LEC中,多巴胺是新奇性诱导的奖励期望信号.
  • 抑制LEC多巴胺破坏了关联编码和学习.

结论:

  • 这样一来, LEC 风扇细胞就形成了抽象任务规则的认知地图.
  • LEC 多巴胺促进了新的记忆融入这个认知地图.