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Updated: Oct 19, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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微细胞通过道纳米管的分发共同降解纤维状α-synuclein载荷

Hannah Scheiblich1, Cira Dansokho1, Dilek Mercan1

  • 1Department of Neurodegenerative Disease and Geriatric Psychiatry/Neurology, University of Bonn Medical Center, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.

Cell
|September 23, 2021
PubMed
概括

微细胞形成网络以转移和降解α-syn纤维素,这是神经退行性疾病的关键过程. 这种网络形成有助于清除,但受到LRRK2突变的影响.

关键词:
其他类型阿尔法-同核素细胞间的转移进行清理降解情况微质细胞细胞核病变道化纳米管

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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