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鼠标t复合体近端部分的遗传分析:证据表明t单元型中存在第二次反转

B Herrmann, M Bućan, P E Mains

|February 14, 1986

概括

研究人员使用微解剖克隆绘制了小鼠染色体17的地图. 他们发现t类平分类的近位反转很大,解释了异合的小鼠中抑制的重组.

科学领域:

遗传学是一个遗传学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

17号染色体上的小鼠t复合体对于胚胎发育至关重要.
T类平分类与遗传重组和抑制的重组有关.

研究的目的:

为了生成小鼠染色体17的近位区域的高分辨率遗传图.
为了研究野生类型和型形式的遗传结构.

主要方法:

微解剖克隆小鼠t复杂的基因组序列.
基因映射使用复合同血统菌株分析.
部分t单元类型的分析.

主要成果:

创建了近接染色体17的高分辨率遗传图.
在近接t单元类型中发现了大量的遗传物质逆转,包括T和qk位点.
这种近距离的反转,以及已知的远距离的反转,解释了抑制的重组.

结论:

鉴定到的近位逆转是t类单元型的一个关键特征.
近位和远位逆转的组合解释了异合的小鼠中抑制的重组.
这些发现促进了对染色体结构和重组抑制的理解.

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