通过视网膜酸调节前额外模式和连接性
Mikihito Shibata1, Kartik Pattabiraman1,2, Belen Lorente-Galdos1
1Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Nature
|October 2, 2021
概括
在灵长类动物中,视网膜酸梯度指导前额叶皮层 (PFC) 的发育和连接. 这种信号分子对于PFC及其独特的分层结构的进化扩张至关重要.
科学领域:
- 神经科学
- 发育生物学
- 遗传学
背景情况:
- 前额叶皮质 (PFC) 和它的乳头连接对于工作记忆等认知功能至关重要.
- 在PFC发育中出现的障碍与自闭症和精神分裂症等神经系统疾病有关.
- 对于PFC的发展机制及其独特的灵长类扩张仍然不太清楚.
研究的目的:
- 研究视网膜酸信号在灵长类动物PFC发育中的作用.
- 在人类和的新皮层中识别受视网膜酸调节的基因.
- 了解视网膜酸对PFC - 背中丘脑连接和皮层扩张的作用.
主要方法:
- 在人类和的新皮质发育中的视网膜酸梯度分析.
- 识别可合成视网膜酸和可消化酶 (例如,CYP26B1).
- 在小鼠中进行基因操纵以研究视网膜酸受体 (RXRG,RARB) 和CYP26B1的功能.
主要成果:
- 在PFC中丰富的前后视网酸梯度被确定.
- 观察了灵长类动物特异性的视网膜酸合成和CYP26B1介导的信号传递.
- 视网酸信号传递,RXRG,RARB和CYP26B1对于PFC模式,连接性和第四层的发展至关重要.
结论:
- 视网酸信号在灵长类PFC的分子模式和发展中起着至关重要的作用.
- 这种信号通路可能是PFC的进化扩张的基础.
- 这些发现提供了与PFC功能障碍相关的认知障碍的发展基础.
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