湿性食道炎:一个回顾
1Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
JAMA
|October 5, 2021
概括
性食道炎 (EoE) 是一种慢性食道疾病,影响超过34/100,000人. 治疗包括PPI,类固醇和饮食改变,
科学领域:
- 胃肠病学
- 免疫学
- 病理学
背景情况:
- 乙酸性食道炎 (EoE) 是一种慢性,免疫媒介的食道疾病.
- 它影响儿童和成年人,导致消化不良和食道狭窄.
- 在全球范围内,患病率约为每10万人中有34.4人.
研究的目的:
- 审查目前对乙酸性食道炎 (EoE) 的理解.
- 总结EoE的诊断标准和治疗选择.
- 评估各种治疗干预措施的有效性.
主要方法:
- 对观察性研究进行系统审查.
- 随机对照试验的系统审查.
- 对质子抑制剂和局部皮质类固醇的组织反应率的分析.
主要成果:
- 质子抑制剂 (PPI) 治疗显示组织学反应率为41. 7%,而安慰剂为13. 3%.
- 局部皮质类固醇在64. 9%的患者实现了组织学缓解,而安慰剂患者为13. 3%.
- 消化管扩张适用于症状狭窄的患者.
结论:
- 这是一种严重的食道疾病,需要针对性的治疗.
- 质子抑制剂和局部皮质类固醇是有效的治疗方法.
- 饮食修改和内镜扩张也是关键的管理策略.
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