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相关概念视频

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

347
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
347
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

256
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
256
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

317
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
317
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

259
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
259
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

189
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
189
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

612
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
612

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相关实验视频

Updated: Oct 18, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

991

湿性食道炎:一个回顾

Amanda Muir1, Gary W Falk2

  • 1Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

JAMA
|October 5, 2021
PubMed
概括

性食道炎 (EoE) 是一种慢性食道疾病,影响超过34/100,000人. 治疗包括PPI,类固醇和饮食改变,

科学领域:

  • 胃肠病学
  • 免疫学
  • 病理学

背景情况:

  • 乙酸性食道炎 (EoE) 是一种慢性,免疫媒介的食道疾病.
  • 它影响儿童和成年人,导致消化不良和食道狭窄.
  • 在全球范围内,患病率约为每10万人中有34.4人.

研究的目的:

  • 审查目前对乙酸性食道炎 (EoE) 的理解.
  • 总结EoE的诊断标准和治疗选择.
  • 评估各种治疗干预措施的有效性.

主要方法:

  • 对观察性研究进行系统审查.
  • 随机对照试验的系统审查.
  • 对质子抑制剂和局部皮质类固醇的组织反应率的分析.

主要成果:

  • 质子抑制剂 (PPI) 治疗显示组织学反应率为41. 7%,而安慰剂为13. 3%.
  • 局部皮质类固醇在64. 9%的患者实现了组织学缓解,而安慰剂患者为13. 3%.
  • 消化管扩张适用于症状狭窄的患者.

结论:

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  • 这是一种严重的食道疾病,需要针对性的治疗.
  • 质子抑制剂和局部皮质类固醇是有效的治疗方法.
  • 饮食修改和内镜扩张也是关键的管理策略.