用于独立控制前额信号和噪声的thalamic电路
Arghya Mukherjee1,2, Norman H Lam1,2, Ralf D Wimmer1,2
1McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nature
|October 6, 2021
概括
在不确定性下有两条不同的途径从中背丘脑到前额叶皮质对决策进行不同的调节. 一个途径在稀疏输入时放大信号,而另一个途径在密集,相互冲突的输入时抑制噪音.
科学领域:
- 神经科学
- 认知科学
- 决策研究
背景情况:
- 中背丘脑和前额叶皮层的相互作用对认知功能至关重要.
- 之前的人类研究表明,这些相互作用解决了决策的不确定性,但潜在的机制仍然不清楚.
研究的目的:
- 在不确定性下确定决策的不同神经机制.
- 阐明中背丘脑向前额皮层投射的特定作用.
主要方法:
- 调查了两个截然不同的中背丘脑向前额皮层的投射.
- 在决策任务中表达多巴胺受体 (D2) 和酸盐受体 (GRIK4) 的作用.
主要成果:
- 当任务输入稀疏时,D2表达投影会放大前额信号.
- 当任务输入密集且相互冲突时,GRIK4表达投影会抑制前额噪声.
- 识别出不同的神经机制来处理低信号与高噪音的不确定性.
结论:
- 这些发现揭示了在管理不同类型的不确定性方面,特定的甲状腺皮层途径的互补作用.
- 提供了关于决策过程和治疗前额叶皮层相关疾病的潜在目标的机制性见解.
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