小鼠皮质 - 基底腺体 - 胸膜网络
Nicholas N Foster1,2, Joshua Barry3, Laura Korobkova4
1UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. nnfoster@mednet.ucla.edu.
Nature
|October 7, 2021
概括
研究人员绘制了大脑皮质-基底-甲状腺-皮质循环, 揭示了六个平行子网络. 这种详细的绘图有助于我们更好地了解大脑的功能和疾病.
科学领域:
- 神经科学
- 系统神经科学
- 计算神经科学
背景情况:
- 皮质 - 基底 - 甲状腺 - 皮质环对于认知和行为至关重要.
- 经典的三通道模型 (运动,边缘,关联) 不足以解释基底腺功能.
研究的目的:
- 绘制背脊条状区域的多突触输出路径.
- 在皮质-基底-甲状腺-皮质循环中识别功能子网络.
主要方法:
- 在皮层输入的基础上,将脊椎条纹体细分为功能领域.
- 通过体外部 (GPe),黑质网状部分 (SNr) 和乳头追踪多突触输出.
- 识别SNR,GPe和胸膜领域以及皮层-SNR投射.
主要成果:
- 确定了14个SNR和36个GPe域.
- 六个胸膜领域的划定 (副筋和腹膜核).
- 发现了六个平行皮质 - 基底 - thalamic子网络与闭环组织.
结论:
- 这项研究揭示了前所未知的皮质 - 基底 - 甲状腺 - 皮质循环的复杂组织.
- 六个并行子网络连续处理特定的皮质信息.
- 这种详细的绘图为了解大脑功能和神经系统疾病提供了框架.
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