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在胰腺癌中局限于空间的子瘤微环境

Barbara T Grünwald¹, Antoine Devisme², Geoffroy Andrieux³

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

|October 13, 2021

概括

在胰腺癌中瘤微环境 (TME) 的异质性不是随机的. 我们根据纤维细胞状态确定了不同的"亚TME", 影响瘤免疫力,进展和化疗反应.

科学领域:

癌症学
癌症生物学
瘤微环境研究

背景情况:

内异质性是恶性进展的关键驱动因素.
了解瘤微环境对于癌症研究至关重要.

研究的目的:

通过整合多OMIC数据来解人类胰腺TME.
鉴定胰腺TME中的不同组织状态及其临床相关性.

主要方法:

基于组织学指导的区域多OMIC数据的大规模整合.
对临床数据和患者衍生的临床前模型的分析.
单细胞转录学和现场分析.

主要成果:

发现了
它们是什么?
与纤维细胞可塑性相关的组织状况.
"反应性"亚TME与免疫热瘤和攻击性表型相关.
"被遗弃"的亚TME与瘤抑制和化学保护有关.

结论:

胰腺TME异质性被组织成称为子TME的基本组织单元.
纤维细胞可塑性是定义这些亚TME的核心.
亚TME预测患者特定的表型,异质性和治疗反应.

关键词:

与癌症相关的纤维细胞胰腺癌患者产生的有机物蛋白质组学结构异质性系统生物学处理阻力瘤微环境

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The Tumor Microenvironment

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