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在生理pH下用于快速化物形成的化酸的基于机制的设计

Matthias Tanriver1, Yi-Chung Dzeng1, Sara Da Ros1

  • 1Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich 8093, Switzerland.

Journal of the American Chemical Society
|October 14, 2021
PubMed
概括

新的三甲酸盐 (KAT) 能够在中性pH下与酸胺形成快速的胺基键. 这一突破克服了酸性条件的局限性,为体内应用和生物分子结合铺平了道路.

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