相关实验视频

Updated: Oct 17, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

细胞纳米海绵的表面甘氨酸修饰以促进SARS-CoV-2的抑制

Xiangzhao Ai¹, Dan Wang¹, Anna Honko²

¹Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, California 92093, United States.

Journal of the American Chemical Society

|October 14, 2021

概括

在细胞纳米海绵上增加肝素可以增强严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 的抑制. 这种模仿宿主纳米粒子的策略通过准其尖端蛋白质有效地中和病毒.

科学领域:

生物技术
病毒学
纳米医学

背景情况:

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 使用其尖端 (S) 蛋白进行细胞结合和进入.
这种S蛋白与人类的血管素转化酶2 (ACE2) 受体和像肝素这样的糖氨基酸相互作用.
模仿宿主细胞的细胞纳米海绵通过吸引和中和病毒提供广泛的抗病毒方法.

研究的目的:

研究表面肝素密度对细胞纳米海绵对SARS-CoV-2抑制的影响.
使用模仿宿主纳米粒子的甘工程开发增强的抗病毒策略.

主要方法:

使用表达亚酸的宿主细胞膜制造细胞纳米海绵.
氨酸与纳米海绵表面结合,以改变表面氨酸密度.
评估了对SARS-CoV-2感染性的结合能力和抑制效果.

主要成果:

细胞纳米海绵具有增加的表层肝素密度,显示其对病毒S蛋白的结合增强.
较高的肝素密度显著提高了对SARS-CoV-2感染的抑制效果.
表面甘氨酸工程被证明是增强纳米海绵抗病毒活性的一种简单方法.

结论:

表面肝素密度是细胞纳米海绵对SARS-CoV-2的抗病毒功效的一个关键因素.
这种模仿宿主纳米粒子的方法为对抗SARS-CoV-2提供了有希望的策略.
甘氨酸工程方法可用于开发针对其他依赖甘氨酸的病毒的抑制剂.

更多相关视频

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

Published on: November 25, 2017

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling

Published on: February 5, 2018

相关概念视频

Glycocalyx and its Functions

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.