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Updated: Oct 16, 2025

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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在mRNA-1273疫苗增强的非人类灵长类动物中对SARS-CoV-2Beta变体的保护

Kizzmekia S Corbett1, Matthew Gagne1, Danielle A Wagner1

  • 1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|October 21, 2021
PubMed
概括

用mRNA-1273或mRNA-1273.β进行增强疫苗接种,增强了对SARS-CoV-2关注变体 (VOC) 的中和抗体反应. 这种免疫增强减少了非人类灵长类动物的病毒复制.

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Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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