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Updated: Oct 15, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

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Pd/GF-催化不对称的三组件合反应以获取奇拉尔二甲基

Guofeng Zhao¹, Yi Wu¹, Hai-Hong Wu¹

¹Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, People's Republic of China.

Journal of the American Chemical Society

|October 26, 2021

概括

研究人员开发了一种新的Pd催化合反应,用于制造性二甲基. 这种方法使用易于获得的原料和一种新奇的性配体,提供一种简单的合成有价值的有机化合物的方法.

科学领域:

有机化学
催化剂
不对称的合成

背景情况:

在有机合成中,选择性转化N-托西尔是很重要的.
开发对这些转换的反选择性方法存在重大挑战.

研究的目的:

报告一种新的Pd催化三元合反应.
通过使用新型的性联体,便于获得性二甲基基.

主要方法:

使用了催化三元合反应.
使用了一种新型的化硫胺联体 (GF-Phos).
在温和条件下反应的N-托西尔化物和终端.

主要成果:

成功合成了具有高反选择性的性二甲基.
证明使用相同的配体可以获得该产品的两种酶体.
展示了一般的基板范围和扩展的方便性.

结论:

开发的方法提供了一种通用而高效的途径,
反应的特点是温和的条件,易于获得的原料和高的反选择性.
这种方法促进了含有甲基基基架的分子的合成,这与生物活性化合物有关.

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