在已确定的心血管疾病或糖尿病患者的功能范围内使用Icosapent Ethyl的好处: REDUCE- IT RENAL
在PubMed上查看摘要
概括
此摘要是机器生成的。在患有慢性病 (CKD) 和高血糖水平的患者中,Icosapent ethyl有效降低了心血管事件. 在所有估计的球过率 (eGFR) 类别中,治疗显示出一致的益处,包括功能下降的患者.
科学领域
- 心脏病学
- 肝脏病学
- 药理学
背景情况
- 慢性病与心血管疾病或糖尿病患者的不良结果有关.
- 在功能受损的患者中,标准的心血管疾病药物通常效果较差.
研究的目的
- 在REDUCE- IT试验中分析icosapent ethyl在不同程度的功能患者中的疗效.
- 评估icosapent乙烯对不同估计膜过率 (eGFR) 类别的心血管事件的影响.
主要方法
- 在 REDUCE- IT 试验中,随机分别将三糖化物升高和高心血管风险的他类药物治疗患者分别分给icosapent 乙烯或安慰剂.
- 根据基线eGFR对患者进行分层,以评估治疗对初级和二级复合终点的影响.
主要成果
- 在所有EGFR类别中,Icosapent乙烯始终降低了初级和二级复合心血管终点.
- 在EGFR<60mL·min-1.73m-2的患者中,主要终点的绝对风险降低幅度最大 (HR,0.71).
- 在所有EGFR类别中,心房/和严重出血的发病率相似,尽管在最低EGFR组的发病率比较高.
结论
- 在患有心血管风险因素和不同水平的功能患者中,Icosapent ethyl 已证明有效降低缺血事件.
- 在整个eGFR频谱中观察到icosapent乙烯的益处,支持其在慢性病患者中的使用.
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