轨道前皮层绘制未来的导航目标
Raunak Basu1, Robert Gebauer2, Tim Herfurth2
1Max Planck Institute for Brain Research, Frankfurt am Main, Germany. raunak.basu@brain.mgp.de.
Nature
|October 28, 2021
概括
鼠前轨皮层 (OFC) 中的神经元创建空间地图, 持续指向导航目标. 这个大脑区域对于感官感知之外的精确导航至关重要.
科学领域:
- 神经科学
- 认知科学
- 行为科学
背景情况:
- 准确的导航依赖于持续的空间关系估计.
- 在导航过程中海马神经元在目的地确定中的作用受到争议.
- 现在还不清楚大脑是否能准确地估计目标位置.
研究的目的:
- 调查神经机制的基础准确的目标导航.
- 在导航过程中代表未来的目的地.
- 探索轨道前皮层在空间导航中的功能.
主要方法:
- 在导航任务中记录大鼠轨道前皮层 (OFC) 中的神经活动.
- 分析与目标表示相关的神经组合动态.
- 扰乱OFC活动以观察对导航行为的影响.
主要成果:
- 发现OFC神经元形成空间表征, 持续指向动物的目标目的地.
- 在导航开始之前观察到的目的地编码,没有感觉目标访问.
- 发现OFC活动可以预测导航错误,
- 证明在航行开始时扰乱OFC活动会导致导航错误.
结论:
- 轨道前皮层 (OFC) 是大脑内部目标图的组成部分.
- OFC神经元组保持对航行至关重要的目的地特定表示.
- OFC能够准确地导航到所选择的目的地,即使是在传感范围之外.
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