在水中的化腔体和宿主:曲客体,形状选择性和封装
Ji-Min Yang1, Yong-Qing Chen2, Yang Yu2
1Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Journal of the American Chemical Society
|November 11, 2021
概括
合成了两种新型的水溶性腔体和宿主. 这些容器化合物选择性地结合各种客体,包括基,水友化合物和异构体,使分离应用成为可能.
科学领域:
- 超分子化学
- 有机合成
- 主机与客户之间的化学反应
背景情况:
- 卡维坦是以其封装客分子的能力而闻名的宏环化合物.
- 修改腔体结构可以改变它们的结合性和溶解性.
- 化的开端可以预先将洞穴组织成特定的形状以识别客人.
研究的目的:
- 合成和描述具有预先组织,刚性结构的新型水溶性腔体和宿主.
- 研究这些腔体对各种客分子的结合亲和性和选择性.
- 探索这些腔体在分离过程中的潜在应用.
主要方法:
- 两种不同的水溶性腔体的合成,具有不同的桥梁单元 ((CH2) 4和CH2CH2OCH2CH2).
- 使用光谱和分析技术对合成的腔体进行表征.
- 用一系列客体进行结合性研究,包括环基,n-基,亲水化合物和异构体.
主要成果:
- 由于硬化间隔器,合成的腔体采用了花瓶状的形状.
- 在小和环中观察到1:1复合,在腔内自由运动.
- 观察到各种客体的选择性结合和复合,包括异构体和长链二醇/二胺,导致囊或U形形状.
- 通过提取,以太结合的洞在将氧基烯从异构体中分离的过程中被证明是有用的.
结论:
- 设计的隔离器有效地预先组织了洞穴,增强了它们的宿主特性.
- 新的体具有可调节的结合能力和对各种客分子的选择性.
- 这些水溶性腔体对分子识别和分离技术的应用具有前景.
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