与自闭症相关的饮食偏好调解了自闭症与肠道微生物组的关联
Chloe X Yap1, Anjali K Henders2, Gail A Alvares3
1Mater Research Institute, The University of Queensland, Woolloongabba, Queensland 4102, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia; Cooperative Research Centre for Living with Autism (Autism CRC), Long Pocket, Queensland 4068, Australia.
Cell
|November 12, 2021
概括
自闭症谱系障碍 (ASD) 与肠道微生物群的差异没有直接联系. 相反,对自闭症的兴趣与饮食的多样性有关,
科学领域:
- 微生物组研究
- 神经发育障碍
- 自闭症谱系障碍 (ASD)
背景情况:
- 人们对肠道微生物在自闭症中的作用越来越感兴趣.
- 之前的研究缺乏实力和全面的混因素分析.
- 需要对肠道微生物与ASD的联系进行严格的调查.
研究的目的:
- 研究肠道微生物组组成与自闭症诊断之间的关联.
- 探索影响ASD微生物组差异的潜在混因素.
- 澄清自闭症,饮食和肠道微生物之间的关系.
主要方法:
- 澳大利亚自闭症生物库和昆士兰双胞胎青少年大脑项目的参与者进行了大规模的便转基因组学研究 (n=247).
- 与自闭症诊断和相关特征相关的微生物组组成分析.
- 检测与年龄,饮食摄入量和便一致性的统计能力.
主要成果:
- 在ASD诊断和肠道微生物组合之间发现了微不足道的直接关联.
- 与自闭症相关的兴趣与不太多样化的饮食有关.
- 由于饮食摄入量受到限制,减少了微生物多样性和便的松散度.
- 强烈检测出与年龄,饮食和便一致性的微生物组关联.
结论:
- 自闭症的肠道微生物群差异可能是与诊断特征相关的饮食偏好的次要因素.
- 没有证据支持肠道微生物在自闭症的直接因果关系.
- 建议对微生物组驱动自闭症发展的说法保持谨慎.
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