Search

Search

这页已由机器翻译。其他页面可能仍然显示为英文。 View in English

首页
...
研究领域农业,兽医和食品科学兽医科学兽医病毒学
海地儿童中猪三角型冠状病毒的独立感染

海地儿童中猪三角型冠状病毒的独立感染

John A Lednicky ^1,2, Massimiliano S Tagliamonte ^1,3, Sarah K White ^1,2, Maha A Elbadry ^1,2, Md Mahbubul Alam ^1,2, Caroline J Stephenson ^1,2, Tania S Bonny ^1,2, Julia C Loeb ^1,2, Taina Telisma ⁴, Sonese Chavannes ⁴, David A Ostrov ^1,3, Carla Mavian ^1,3, Valery Madsen Beau De Rochars ^1,5, Marco Salemi ^6,7, J Glenn Morris ^8,9

John A Lednicky ^1,2, Massimiliano S Tagliamonte ^1,3, Sarah K White ^1,2

¹Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
²Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
³Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
⁴Christianville Foundation, Gressier, Haiti.
⁵Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
⁶Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. salemi@pathology.ufl.edu.
⁷Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. salemi@pathology.ufl.edu.
⁸Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. jgmorris@epi.ufl.edu.
⁹Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. jgmorris@epi.ufl.edu.

⁰Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

Nature +

|

2021年十一月18日

相关实验视频

These videos have been matched automatically. Contact us if they are not relevant.

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity

Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity

Published on: November 22, 2021

See all related videos

在PubMed上查看摘要

概括

此摘要是机器生成的。

在海地儿童中检测到猪三角型冠状病毒 (PDCoV),表明至少有两种独立的动物传播. 这些发现揭示了新型冠状病毒感染人类的可能性,扩大了已知的冠状病毒群.

科学领域

病毒学
动物传染病
基因组学
进化生物学

背景情况

冠状病毒引起了重大流行病,包括SARS-CoV-2大流行病,主要是通过动物库的动物传播.
从历史上看,人类感染与阿尔法冠状病毒和贝塔冠状病毒有关,其他类型的威胁较少.
了解能够感染人类的冠状病毒的全谱对于疫情准备至关重要.

研究的目的

确定海地儿童急性不分化的发烧病的原因.
调查已知与人类相关的群体之外的冠状病毒可能导致动物感染.
分析人类新发现的冠状病毒菌株的基因组和进化特征.

主要方法

在受影响儿童的血样本中检测猪三角型冠状病毒 (PDCoV) 菌株.
对已识别的PDCoV菌株进行全面的基因组测序和基因组分析.
病毒蛋白的结构分析,重点是尖端糖蛋白及其受体结合域.

主要成果

在三名患有发烧疾病的海地儿童中发现了PDCoV菌株.
基因组和进化分析表明至少有两种不同的PDCoV血统的动物性溢出事件发生在人类身上.
在编码Nsp15和尖端糖蛋白的基因中观察到关键突变,可能会影响宿主细胞受体的结合.

结论

这项研究确定了猪三角型冠状病毒是人类感染的原因,扩大了已知的可传播动物间的冠状病毒范围.
这些发现凸显了以前未被认可的群体中的冠状病毒适应并引起人类疾病的潜力.
人与动物的密切接触可能会促进新型动物性冠状病毒的出现,强调需要加强监测.

相关实验视频

这些视频已自动匹配 Contact us 如果它们不相关

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity

Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity

Published on: November 22, 2021

See all related videos

相关概念视频

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

Viral Recombination Can Create New Diseases

Some diseases can infect multiple species. For example, pigs can be infected by some human and...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies