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克里斯普尔屏幕揭示了T细胞免疫的营养许可信号枢纽

Lingyun Long1, Jun Wei1, Seon Ah Lim1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|November 19, 2021
PubMed
概括

营养素通过影响RAPAMYCIN复合体1 (mTORC1) 的机械标来调节适应性免疫. 这项研究确定了控制mTORC1信号的SEC31A和CCDC101等关键蛋白质,影响T细胞功能和免疫耐受性.

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