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Updated: Oct 12, 2025

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可光激活抗癌复合物的单细胞化学

Elizabeth M Bolitho1,2, Carlos Sanchez-Cano3, Huayun Shi1

  • 1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom.

Journal of the American Chemical Society
|November 22, 2021
PubMed
概括

光激活化疗剂, (IV) 前药Pt1和Pt2,显示光诱导的癌细胞死亡. Pt2导致显著的细胞损伤和Pt积累,可能涉及光激发 (IV) 种.

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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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