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ecDNA枢纽驱动合作性分子间瘤基因表达

King L Hung1, Kathryn E Yost1, Liangqi Xie2,3,4

  • 1Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|November 25, 2021
PubMed
概括

外染色体DNA (ecDNA) 枢纽聚集在一起,使得癌基因在癌症中过度表达. 一种叫做BRD4的蛋白质结合了这些枢纽, 抑制它减少了癌基因转录, 提供了潜在的癌症治疗点.

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