遗传祖先对病毒感染反应的影响是普遍的,但特定于细胞类型
Haley E Randolph1, Jessica K Fiege2,3, Beth K Thielen4
1Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.
概括
遗传血统影响了流感的免疫反应,欧洲血统与更强的早期干扰素活性和更好的病毒控制有关. 这些发现可能会扩展到COVID-19等其他病毒感染.
科学领域:
- 免疫学
- 遗传学
- 传染性疾病
背景情况:
- 人类对传染病的易感性因感染后免疫反应的差异而有所不同.
- 遗传血统是影响免疫系统变化的已知因素.
研究的目的:
- 根据遗传血统量化对流感感染的免疫反应的变化.
- 研究遗传祖先对免疫反应的影响的细胞类型特异性.
主要方法:
- 用单细胞RNA测序分析了周围血液的单核细胞.
- 从欧洲和非洲祖先的男性中采集了流感感染后的外周血液单核细胞.
主要成果:
- 发现遗传对免疫反应的影响是细胞类型特异性的.
- 在早期感染期间,欧洲血统增加与I型干扰素通路活性增加相关.
- 这种早期的干扰素活性预测了感染过程中病毒标位的下降.
- 人口相关变异在很大程度上是由基因祖先之间存在差异的 cis 表达量特征位点 (eQTL) 解释的.
- 与遗传血统相关的基因在与COVID-19疾病严重程度相关的基因中呈现丰富性.
结论:
- 遗传血统显著影响了对流感的早期免疫反应.
- 与祖先相关的确定的免疫反应途径可能导致多种病毒感染,包括COVID-19的差异性结果.
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