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在CAR T细胞功能障碍中发生NK类CAR T细胞转变

Charly R Good1, M Angela Aznar2, Shunichiro Kuramitsu2

  • 1Department of Cell and Developmental Biology, Penn Institute of Epigenetics, Perelman School of Medicine, Philadelphia, PA 19104, USA.

Cell
|December 3, 2021
PubMed
概括

化学抗原受体 (CAR) T细胞疗法对固体瘤具有前景. 研究人员发现向SOX4和ID3可以防止CART细胞耗尽,提高治疗效率.

关键词:
一个 CAR T 单元标签 ID3类似NK的T细胞一个SOX4T细胞功能障碍T细胞耗尽癌症细胞移植疗法免疫学免疫疗法胰腺癌一个细胞RNA-seq

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