由血红蛋白引起的疟疾保护取决于寄生虫的基因型
Gavin Band1,2,3, Ellen M Leffler4,5, Muminatou Jallow6,7
1Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. gavin.band@well.ox.ac.uk.
Nature
|December 9, 2021
概括
血球 (HbS) 提供抗疟疾的药物. 这项研究将HbS与特定的Plasmodium falciparum寄生虫基因区域联系起来,表明疟疾流行地区的共同进化和适应.
科学领域:
- 遗传学
- 进化生物学
- 寄生虫学
背景情况:
- 宿主遗传因素,如状血红蛋白 (HbS),赋予了对疟疾的抵抗力.
- 疟疾寄生虫群体对宿主耐药性的进化适应尚未得到充分理解.
研究的目的:
- 在患有严重疟疾的儿童中调查宿主遗传变异 (HbS) 和虫寄生虫遗传变异之间的联系.
- 确定与HbS驱动疟疾相关的特定寄生虫基因组区域.
主要方法:
- 对3346名严重疟疾的冈比亚和肯尼亚儿童进行基因组分析.
- 主体HbS状态与Plasmodium falciparum遗传变体之间的关联研究.
- 在额外的样本组中复制结果.
主要成果:
- 在宿主HbS和Plasmodium falciparum基因组的三个特定区域之间发现了强烈的关联.
- 这些相关的寄生虫等位基因在非洲比较常见,与HbS的患病率相关.
- 根据这些位点的寄生虫基因型,HbS对严重疟疾的保护作用有显著差异.
结论:
- 这些发现表明Plasmodium falciparum和宿主HbS之间的共同进化适应.
- 已识别的寄生虫多态体代表了研究疟疾的生物和流行病学意义的新领域.
- 这些等位基因在非洲寄生虫群体中的高频率和链接不平衡表明强大的进化压力.
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