一个基因定义的脑干电路选择性地控制了动机活力
Hanfei Deng1, Xiong Xiao1, Tao Yang1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Cell
|December 10, 2021
概括
前岛皮层 (aIC) 通过Fezf2神经元发出动机活力信号,影响寻求需求的行为. 这种循环调节了运动和多巴胺的释放,
科学领域:
- 神经科学
- 行为神经科学
- 如何做出决定
背景情况:
- 前部岛内皮质 (aIC) 对于行为控制至关重要,但其精确的神经机制尚未完全理解.
- 在aIC中的pyramidal tract神经元涉及认知和动机过程.
研究的目的:
- 阐明神经系统控制动机活力和寻求需求的机制.
- 确定参与调节动机行为的特定神经元群体和电路.
主要方法:
- 使用基因标记来识别和准aIC中的Fezf2表达神经元 (aICFezf2).
- 研究了从aIC到单独细胞核 (NTS) 的神经元活动和电路投射.
- 研究了aIC → NTS电路在控制行为,多巴胺释放和消耗方面的作用.
主要成果:
- aICFezf2神经元通过向NTS投射信号激发动机活力,并激发需求寻求行为.
- 通过学习获得的aICFezf2和NTS神经元中的预测活动编码了对同居需要的感知价值和行动活力.
- 该aIC → NTS电路选择性地控制活力,精力和条形多巴胺释放,取决于学习的行为和需要.
- aICFezf2神经元并不代表味道或价值,电路也不能驱动强化或总消耗.
结论:
- 确定了aIC → NTS电路在控制动机活力的特定功能.
- 这表明动机部分由aIC的自上而下的多巴胺信号调节介导.
- 突出了aIC中特定神经元群体在调节动机行为的作用.
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