在美国成年人中保持比率损伤的精神测量与临床结果之间的关联
Emily S Wan1,2, Pallavi Balte3, Joseph E Schwartz3,4
1Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts.
JAMA
|December 14, 2021
概括
在美国成年人中,保留比率受损螺旋计 (PRISm) 与增加的死亡率和不良呼吸和心血管结果有关. 这种无阻塞的肺体积减少的情况需要进一步研究其与这些健康问题的因果关系.
科学领域:
- 肺部医学
- 流行病学
- 公共卫生
背景情况:
- 慢性肺部疾病是导致死亡和疾病的主要原因.
- 与COPD相比,没有阻塞的肺体积减少的状态 - - 保持比率受损的精神测量 (PRISm) 的临床结果尚不清楚.
研究的目的:
- 确定PRISm在美国成年人群中的患病率,相关因素和临床结果.
主要方法:
- 使用了来自国家心脏,肺和血液研究所 (NHLBI) 聚合群组研究的数据,该研究包括超过53,000名具有有效的基线肺功能的参与者.
- 根据FEV1:FVC比率和FEV1将参与者分为PRISm,阻塞性精神测量和正常精神测量组.
- 使用调整的Poisson和Cox比例危险模型分析了所有原因死亡率,呼吸道和冠心病 (CHD) 事件的关联.
主要成果:
- 8. 5% 的参与者患有PRISm,这与肥胖,体重不足,女性性别和目前的吸烟有关.
- 与正常精神测量相比,PRISm与全因死亡率 (HR 1. 50),呼吸道死亡率 (HR 1. 95),心血管疾病死亡率 (HR 1. 55),呼吸道事件 (HR 1.90) 和心血管疾病事件 (HR 1. 30) 的风险显著增加.
结论:
- 在大量美国人群中,PRIS与死亡率和心血管和呼吸系统不良结果的统计显著增加有关.
- 建议进一步研究PRISm与这些不良健康结果之间的潜在因果关系.
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