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Updated: Oct 10, 2025

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
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An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity

Published on: October 8, 2018

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阅读框架修复TTN截断变种恢复了Titin的数量和功能

Robert Romano1, Shahnaz Ghahremani2, Talia Zimmerman2

  • 1University of Connecticut Health Center, Farmington (R.R., F.A.L., A.M.P., J.T.H.).

Circulation
|December 14, 2021
PubMed
概括

蒂切断变体 (TTNtvs) 导致扩张性心肌病 (DCM). A带TTNtvs具有更强的致病性,损害了瘤的功能和肌纤维生成. CRISPR基因编辑为TTNtvs提供了一个潜在的治疗策略.

关键词:
通过CRISPR介导的读取框架修复美国扩张性心肌病的切断变种

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