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NLRs保护新陈代谢以协调模式和效应器触发的免疫力

Keran Zhai¹, Di Liang^1,2, Helin Li^1,3

¹National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.

|December 16, 2021

概括

的免疫力依赖于PICI1, 这是一种稳定防御化合物的蛋白质. 植物免疫受体保护PICI1免受病原体的作用,确保对大米爆发等疾病具有广泛的抵抗力.

科学领域:

植物免疫力
分子植物病原体相互作用
植物生物化学

背景情况:

植物免疫反应,包括模式触发免疫 (PTI) 和效应器触发免疫 (ETI),涉及防御代谢物.
免疫受体,防御代谢物产生和广泛耐药性之间的协调尚未完全理解.

研究的目的:

确定大米 (Oryza sativa) 中的防御代谢物产生的关键调节剂,以对抗PTI和ETI.
阐明免疫受体与防御途径和广谱抗性的分子机制.

主要方法:

米中的二基因酶PICI1的鉴定和特征
分析PICI1在稳定 metionin合成酶和调节 metionin介导免疫力的作用.
研究PICI1和植物免疫受体 (如PigmR) 之间的相互作用.
检查PICI1基因的自然变异及其对水抗爆的影响.

主要成果:

PICI1 作为免疫枢纽,通过乙烯生物合成去化和稳定 metionin合成酶以促进 metionin介导的免疫力.
爆发性真菌效应器针对PICI1进行降解以抑制PTI.
植物NLRs (例如,PigmR) 保护PICI1免受效应器介导的降解,重新激活免疫反应.
PICI1的自然变化导致了米子种之间的抗爆差异.

结论:

NLR参与了与效应器的进化军备竞赛,利用了以PICI1为媒介的代谢途径为中心的竞争机制.
这一途径同步了PTI和ETI,确保了大米的广泛耐药性.

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