利用力量的力量:开发分子释放机制
Brooke A Versaw1, Tian Zeng1, Xiaoran Hu1
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Journal of the American Chemical Society
|December 20, 2021
概括
机械聚合物在受到压力时释放分子,使其在传感和药物输送中的应用成为可能. 在聚合物机械化学方面需要进一步的进展.
科学领域:
- 聚合物机械化学
- 材料科学
背景情况:
- 在机械力下释放分子的聚合物对于传感,催化和药物输送有价值.
- 机械是聚合物机械化学的关键组成部分,提供可控的有效载荷释放.
研究的目的:
- 审查基于机械的分子释放平台的最新进展.
- 提供对该领域未来进步的批判性观点.
主要方法:
- 机械开发和应用的文献综述.
- 分析基本面和技术上的挑战.
主要成果:
- 机械孔技术可以选择性和受控地释放共价束的有效载荷.
- 在设计和利用机械系统方面取得了显著进展.
结论:
- 基于机械的分子释放平台显示出各种应用的巨大潜力.
- 为了克服现有挑战并充分发挥这项技术的潜力,继续进行研究至关重要.
相关概念视频
01:39Mechanism of Filopodia Formation
2.6K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.6K
01:58Mechanical Protein Functions
5.1K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
5.1K
01:31Mechanism of Lamellipodia Formation
2.8K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.8K
01:18Role of Myosin in Cell Migration
2.5K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.5K
01:13Actin Polymerization and Cell Motility
5.6K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.6K