纤维素会引起口腔粘膜的炎症
Tommaso Vicanolo1, Andrés Hidalgo1
1Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Science (New York, N.Y.)
|December 23, 2021
概括
口腔粘膜上的纤维素沉积会激活中性粒细胞,导致骨破坏. 这项研究突出了口腔组织损伤的关键机制.
科学领域:
- 口腔生物学
- 免疫学
- 牙周病学
背景情况:
- 纤维素是血液凝固的重要蛋白质,可以在组织中积累.
- 口腔粘膜容易发生炎症和组织损伤.
研究的目的:
- 研究纤维素沉积在口腔粘膜内的炎症反应的作用.
- 阐明纤维素有助于中性粒细胞激活和随后的骨破坏的机制.
主要方法:
- 使用体外口腔粘膜模型.
- 在暴露于纤维素时评估中性粒细胞激活标志物.
- 在活性中性粒细胞和纤维素的存在下量化骨质再吸收指标.
主要成果:
- 纤维素沉积被证明可以显著激活中性粒细胞.
- 在纤维素的存在下激活的中性粒细胞诱导了明显的骨破坏.
- 显示纤维素存在与炎症性骨损失之间有直接的相关性.
结论:
- 在口腔粘膜中的纤维素积累是中性粒细胞介导炎症的强有力的触发因素.
- 这一过程直接导致骨破坏,
相关概念视频
01:38Inflammation
56.1K
Overview
56.1K
01:28Inflammatory Response
11.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
11.0K
01:16Clot Retraction and Fibrinolysis
7.4K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
7.4K
01:30Inflammatory Response I: Vascular and Cellular
13.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.0K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
10.0K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.0K
01:22Formation of the Platelet Plug
7.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.7K