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蜜蜂病原体Paenibacillus幼虫的总合成和生物评估

Timur Bulatov1, Sebastian Gensel1, Andi Mainz1

  • 1Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, 10623 Berlin, Germany.

Journal of the American Chemical Society
|December 30, 2021
PubMed
概括

研究人员合成了paenilamicin B2,揭示了其N-终端片段作为一个关键的药物. 这些复杂通过抑制细菌竞争对手并可能作为核糖体抑制剂来对抗美国污染物 (AFB).

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Production of Antibiotics01:27

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
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