使用可移除的O-链接β-N-乙糖胺策略正确折叠的富含硫化物蛋白的总化学合成

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Wei-Wei Shi1, Chaowei Shi, Tong-Yue Wang1

  • 1Tsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing 100084, China.

Journal of the American Chemical Society
|January 3, 2022
PubMed
概括

化学家开发了一种新型可移除的糖化修饰 (RGM) 策略,以简化复杂的,富含硫化物蛋白质的合成. 这种方法稳定了折叠中间体,使得治疗性蛋白质如肝素和介质蛋白-5的有效生产成为可能.

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