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Updated: Oct 7, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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常见的祖先特异性离子通道变异易患药物诱导的心律失常

Yuko Wada, Tao Yang1, Christian M Shaffer1

  • 1Department of Medicine (Y.W., T.Y., C.M.S., L.L.D., A.M.G., G.E.D.), Vanderbilt University Medical Center, Nashville, TN.

Circulation
|January 7, 2022
PubMed
概括

常见的SCN5A变异不会影响基线再极化,但在IKr被阻断时会增加QT延长的风险. 这凸显了药物反应研究中需要多样化的群体.

关键词:
这里是Torsades de Pointes.与药物相关的副作用和不良反应诱导多能干细胞长时间QT综合征肌细胞,心脏通道通道

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