在人体中,SARS-CoV-2 mRNA 疫苗引发了强烈和持久的 T 毛囊辅助细胞反应
Philip A Mudd1, Anastasia A Minervina2, Mikhail V Pogorelyy2
1Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Cell
|January 13, 2022
概括
SARS-CoV-2 的 mRNA 疫苗会产生强烈的免疫反应. 毛囊辅助CD4+T细胞在BNT162b2mRNA疫苗引起的长期免疫力中起着关键作用.
科学领域:
- 免疫学
- 疫苗学
背景情况:
- SARS-CoV-2 mRNA 疫苗产生强大的抗体和 CD4+ T 细胞免疫力.
- 毛囊辅助CD4+T细胞 (TFH) 对mRNA疫苗免疫性的具体贡献尚不清楚.
研究的目的:
- 研究疫苗诱导的TFH细胞在BNT162b2 mRNA疫苗反应中的作用.
- 在接种疫苗后,对TFH细胞受体谱和淋巴结的表型进行鉴定.
主要方法:
- 从接受BNT162b2mRNA疫苗的人身上用细针吸取下淋巴结.
- 分析T细胞受体序列和淋巴结TFH细胞的表型.
- 配对血液和淋巴结样本分析以追踪TFH细胞动态.
主要成果:
- 在具有这种常见HLA基因基因的个体中,鉴定出一种免疫主导的HLA-DPB1*04受限制的TFH对特定的SARS-CoV-2峰值 (S167-180) 的反应.
- 疫苗诱导的循环S特异性TFH细胞在第二次免疫接种后的一周达到峰值.
- 在淋巴结中持续至少六个月的S特异性TFH细胞.
结论:
- 强大的TFH细胞反应对于SARS-CoV-2mRNA疫苗的持续免疫性至关重要.
- 这些发现突显了TFH细胞在BNT162b2mRNA疫苗诱导的长期免疫力的重要作用.
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