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在COVID-19中,cGAS-STING途径驱动了I型IFN免疫病理

Jeremy Di Domizio1, Muhammet F Gulen2, Fanny Saidoune1

  • 1Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.

Nature
|January 19, 2022
PubMed
概括

干扰素基因 (STING) 的循环GMP-AMP合成酶 (cGAS) 刺激途径导致COVID-19的有害炎症. 在小鼠中抑制STING可降低肺炎并改善结果,这表明了新的治疗点.

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