女性和男性的循环代谢和白质超强度
Eeva Sliz1,2, Jean Shin1,2, Shahzad Ahmad3,4
1The Hospital for Sick Children (E.S., J.S., Z.P.), University of Toronto, Canada.
Circulation
|January 20, 2022
概括
这项研究将特定的血液代谢物,如基酸和脂质与成年人白质强度过高 (WMH) 联系起来. 这些发现揭示了WMH风险和性别特异性的潜在生物标志物.
科学领域:
- 神经成像
- 代谢学
- 流行病学
背景情况:
- 白质高强度 (WMH) 是中风,痴呆和死亡的重要危险因素.
- 之前研究了WMH与循环中的代谢物之间的联系,但缺乏大规模研究.
研究的目的:
- 在一个大型的多民族群体中研究循环代谢量和WMH之间的关联.
- 确定可能作为WMH生物标志物的特定代谢物,并探索性别特异性.
主要方法:
- 在8个基于社区的群体中利用了9,290人的数据.
- 使用MRI量化WMH体积,并通过质谱和NMR光谱评估循环代谢物.
- 使用线性回归模型和元分析,根据各种临床和人口因素进行调整.
主要成果:
- 确定了30个与WMH相关的代谢量,其中7个在完全调整后仍然显著.
- 在高基酸盐和WMH之间发现了强烈的关联,特别是在男性中.
- 观察到WMH与较低的酸胆,较低的基米林以及低密度脂蛋白颗粒大小和组成的相关性.
结论:
- 包括脂质和非脂质化合物的循环代谢物与中年和老年人的WMH有关.
- 特定的代谢物,如基酸和各种脂质测量,与WMH有显著的关联.
- 这项研究强调了这些关联的显著性别特异性以及这些代谢物的解释WMH变异的潜力.
相关概念视频
01:24Magnetic Resonance Imaging
7.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.9K
01:21Imaging Studies for Cardiovascular System IV: CMRI
153
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
153