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转变为侵袭性乳腺癌与瘤层的结构和组成的渐进性变化有关

Tyler Risom¹, David R Glass², Inna Averbukh²

¹Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Department of Research Pathology, Genentech, South San Francisco, CA, USA.

|January 22, 2022

概括

在乳腺癌进展期间调查瘤微环境 (TME) 发现了不同的TME状态. 在位管癌 (DCIS) 中的肌皮细胞变化可以防止侵袭性乳腺癌 (IBC) 复发.

科学领域:

癌症学
癌症生物学
免疫学

背景情况:

在位管道癌 (DCIS) 是侵袭性乳腺癌 (IBC) 之前的侵袭性乳腺病变.
了解瘤微环境对于识别乳腺癌进展的驱动因素至关重要.

研究的目的:

在从正常乳腺组织过渡到DCIS和IBC期间描述TME变化.
为了确定IBC复发风险的潜在生物标志物.

主要方法:

在79次手术切除中使用多重离子束成像 (MIBI-TOF).
应用机器学习用于细胞细分,聚类和形态测量.
根据肌皮质,纤维细胞和免疫细胞分布和功能分析了TME状态.

主要成果:

确定了与乳腺癌进展相关的四种协调TME状态.
在DCIS病例中观察到更先进的肌皮干扰,但没有进展到IBC.
表明肌皮质完整性的潜在保护作用,防止复发.

结论:

在调节IBC复发方面,TME起着至关重要的作用.
在DCIS中肌皮细胞状态可以预测未来的侵袭性疾病和复发.
这项研究提供了HTAN乳腺癌前期图谱的洞察力,以了解乳腺癌的演变.

关键词:

美国国家安全局一个 MIBI 乳腺癌肌上皮空间蛋白质组学系统生物学瘤微环境瘤进展情况

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