Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Determination01:51

Determination

19.5K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
19.5K
Vision01:24

Vision

55.8K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
55.8K
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

1.1K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
1.1K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

5.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
5.0K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.7K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.7K
Cellular Differentiation00:57

Cellular Differentiation

4.0K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
4.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Large Language Model-Informed Dual-Track AI Framework for the Synergistic Design of Crack-Free and High-Strength Superalloys.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

ELF3/miR-9-5p/NFKB1 axis promotes the progression of osteoarthritis by triggering NLRP3-mediated cell pyroptosis.

Immunologic research·2026
Same author

Flutamide exacerbates hepatic insulin resistance in type 2 diabetic mice through overproduction of ROS and activation of NLRP3 signaling.

International immunopharmacology·2026
Same author

Comparative transcriptomics reveals differences in cortical cell type organization between metatherian and eutherian mammals.

PNAS nexus·2026
Same author

A bone-derived hormone permits rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons.

Neuron·2026
Same author

MPNFS-based integrative psychological intervention for adolescents with anxiety disorders: effects on anxiety, self-concept, parenting style, family intimacy, and social support.

Frontiers in psychiatry·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
查看所有相关文章

相关实验视频

Updated: Oct 5, 2025

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.1K

在发育中的皮质细胞类型和功能视觉依赖的规范

Sarah Cheng1, Salwan Butrus2, Liming Tan3

  • 1Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell
|January 22, 2022
PubMed
概括
此摘要是机器生成的。

视觉在老鼠视觉皮层的上层形成特定的大脑细胞类型 (V1). 这种依赖经验的发展依赖于基因表达,影响神经元的连接和功能.

关键词:
双眼视力细胞类型关键时期抑制性突触三分之二层一个核的RNA-seq视觉皮层

更多相关视频

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.5K
Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

8.3K

相关实验视频

Last Updated: Oct 5, 2025

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.1K
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.5K
Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System
10:12

Live Imaging of Primary Cerebral Cortex Cells Using a 2D Culture System

Published on: August 9, 2017

8.3K

科学领域:

  • 神经科学
  • 发育生物学
  • 遗传学

背景情况:

  • 产后经验显著影响大脑发育,特别是皮质电路.
  • 了解细胞类型特定的发育轨迹对感官输入的反应仍然是一个挑战.

研究的目的:

  • 研究小鼠初级视觉皮层 (V1) 中视觉体验如何塑造不同的细胞类型.
  • 确定依赖于经验的电路改进的分子机制.

主要方法:

  • 根据细胞类型进行单核RNA测序.
  • 视觉剥夺和基因操纵以评估经验依赖的变化.
  • 用功能成像来评估神经反应.

主要成果:

  • 视觉选择性地驱动上层 (L2/3/4) 谷氨酸性细胞类型的规范.
  • 在眼睛打开之前建立了更深层的谷氨酸,GABA和非神经元细胞类型.
  • 包括Igsf9b在内的经验依赖基因表达调节L2/3中的细胞粘附和突触形成.
  • 在L2/3中,Igsf9b对于正常双眼反应的发展至关重要.

结论:

  • 视觉输入优先调节上层质细胞类型的发展.
  • 细胞类型特定的基因表达程序是视觉体验依赖皮质发展的关键媒介.