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相关概念视频

Vaccinations01:51

Vaccinations

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Overview
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Cross-reactivity00:42

Cross-reactivity

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Overview
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

882
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
882
Development of Immunocompetence01:22

Development of Immunocompetence

485
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
485

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相关实验视频

Updated: Oct 5, 2025

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
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Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

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关于疫苗的奥米克朗信息:增强产生的广度

Duane R Wesemann1

  • 1Department of Medicine, Division of Allergy and Clinical Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Cell
|January 23, 2022
PubMed
概括

SARS-CoV-2 Omicron 避开了中和抗体. 然而,第三剂疫苗增强了免疫记忆,恢复了抗体功能,证明了免疫适应性.

科学领域:

  • 病毒学
  • 免疫学
  • 疫苗学

背景情况:

  • SARS-CoV-2 Omicron 变种的出现对现有的疫苗诱导免疫造成了重大挑战.
  • 中和抗体对于防止病毒进入和感染至关重要.

研究的目的:

  • 研究SARS-CoV-2 Omicron对中和抗体反应的影响.
  • 评估不同疫苗方案对抗Omicron逃避的有效性.

主要方法:

  • 对抗SARS-CoV-2 Omicron的中和抗体标位的分析.
  • 一次,两次和三次疫苗接种后免疫反应的比较.

主要成果:

  • 在SARS-CoV-2 Omicron中,主要疫苗系列诱导的中和抗体具有强烈的逃避能力.
  • 一次或两次剂量方案不足以产生强大的抗Omicron中和抗体.
  • 一种同类的第三剂增强剂显著恢复了对Omicron的中和功能.

结论:

  • 免疫记忆表现出适应性,在SARS-CoV-2变种中扩展抗体的有效性.
  • 增强疫苗对增强和扩大对病毒株的免疫保护至关重要.

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