相关实验视频
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Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
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2020年12月至2021年8月在美国接种mRNA的COVID-19疫苗后报告的心肌炎病例
Matthew E Oster1,2,3, David K Shay1, John R Su1
1US Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA
|January 25, 2022
概括
接种COVID-19疫苗与心肌炎的风险增加有关,特别是在第二剂疫苗接种后的青少年和年轻男性中. 这种风险必须与疫苗接种带来的重大公共健康益处进行权衡.
科学领域:
- 心脏病学
- 免疫学
- 公共卫生
背景情况:
- 接种COVID-19疫苗为公众健康带来了好处,但也带来了潜在的风险,包括心肌炎.
- 接种COVID-19疫苗后肌心炎的确切风险和结果尚不清楚.
研究的目的:
- 在美国进行基于mRNA的COVID-19疫苗接种后调查和报告心肌炎病例及其相关报告率.
- 描述疫苗接种后30岁以下患者心肌炎的临床特征和早期结果.
主要方法:
- 一项描述性研究分析了2020年12月至2021年8月期间提交给疫苗不良事件报告系统 (VAERS) 的肌心炎报告.
- 使用索赔数据计算和比较预期报告率. 对30岁以下患者的临床数据进行了审查.
主要成果:
- 在超过3.54亿剂的mRNACOVID-19疫苗中,有1626例符合心肌炎的定义.
- 在不同的人口群体中,报告率超过预期,在第二剂疫苗接种后,青少年男性 (12-17岁) 和年轻男性 (18-24岁) 的发病率最高.
- 在有临床信息的30岁以下患者中,有98%的患者血红素水平升高,96%的患者住院治疗,大多数患者症状得到缓解.
结论:
- 在多个年龄和性别群体中,mRNA COVID-19 疫苗接种后心肌炎的风险增加,特别是在第二剂疫苗接种后的青少年男性和年轻男性中.
- 鉴定到的这种风险需要与COVID-19疫苗接种的已知好处一起考虑.
- 可能需要进一步的研究,以充分了解疫苗接种后心肌炎的长期影响和治疗.
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