精神分裂症
Sameer Jauhar1, Mandy Johnstone2, Peter J McKenna3
1Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, UK.
精神分裂症是一种复杂的脑部疾病, 研究探讨了它的遗传,环境和神经生物学基础,以及当前和未来的治疗策略.
科学领域:
- 神经科学
- 精神病学
- 遗传学
背景情况:
- 精神分裂症带来了重大的病因和治疗挑战,与人们对其患病率和结果的普遍看法相反.
- 症状分为正面,负面和失序综合征, 认知障碍现在被认为是关键特征.
研究的目的:
- 提供关于精神分裂症病因,临床特征和治疗现有认识的全面概述.
- 讨论正在进行的辩论和精神分裂症的未来研究方向.
主要方法:
- 对精神分裂症的临床表现,神经生物学和遗传学的已知发现的审查.
- 分析目前精神分裂症研究中的治疗方法和新概念.
主要成果:
- 精神分裂症对男性的影响略高于女性,
- 已确定的发现包括大脑结构变化 (心室扩大,体积减少) 和前皮层网络的功能变化.
- 神经化学障碍 (多巴胺,NMDA受体),多基因遗传和早期生活因素都与此有关.
结论:
- 多巴胺受体阻断药物仍然是主要的治疗方法,认知行为治疗的效果有限.
- 精神分裂症越来越多地被视为连续性的极端,关于大麻和童年逆境等致病因素以及早期干预的影响正在进行辩论.
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