通过氧化纳米粒子产生近红外激发反应性氧物种
Dida Duosiken1, Ruihao Yang1, Yingfan Dai1
1State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Journal of the American Chemical Society
|February 4, 2022
概括
当暴露在近红外 (NIR) 光线下时,氧化纳米粒子有效地产生反应性氧物种 (ROS). 这些纳米粒子对光动力疗法 (PDT) 和光催化等其他应用具有前景.
科学领域:
- 材料科学
- 纳米技术
- 生物医学工程
背景情况:
- 开发用于近红外 (NIR) 光触发反应性氧物种 (ROS) 的材料对于各种科学和工业应用至关重要.
- 图 (Tm) 离子具有独特的光物理特性,使其成为NIR吸收和能量转移的候选者.
研究的目的:
- 研究氧化物纳米粒子 (Tm2O3NP) 作为NIR激活的ROS生成器.
- 评估Tm2O3NP在光动力疗法 (PDT) 中对瘤抑制的疗效.
主要方法:
- 氧化纳米颗粒的合成和表征.
- 评估NIR刺激的ROS生成能力.
- 在使用宽带素灯和808nm激光器的PDT模型中对Tm2O3NP进行体内评估.
主要成果:
- 图氧化物纳米颗粒显示出高效的NIR刺激的ROS生成.
- 离子的光物理特性,包括能量水平和激发状态寿命,支持这种功能.
- 在使用这些纳米粒子的PDT实验中观察到显著的瘤抑制.
结论:
- 氧化硫纳米粒子是有效的NIR激活ROS生成器.
- 在光动力疗法中,Tm2O3NP具有显著的应用潜力.
- 这些发现表明光催化,环境修复和化学合成的应用范围更广.
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