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在癌症中绘制集群突变显示了ecDNA的APOBEC3突变

Erik N Bergstrom1,2,3, Jens Luebeck4,5, Mia Petljak6

  • 1Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.

Nature
|February 10, 2022
PubMed
概括

这项研究全面分析了2583个癌症基因组中的集群突变,揭示了多种突变过程及其与癌症驱动基因和患者生存的联系. APOBEC3在促进染色体外DNA进化方面发挥着关键作用.

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