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Updated: Oct 4, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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质母细胞瘤突变改变了EGFR二分体结构,以防止连接物偏差

Chun Hu1,2, Carlos A Leche1,2, Anatoly Kiyatkin1,2

  • 1Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.

Nature
|February 10, 2022
PubMed
概括

在表皮生长因子受体 (EGFR) 中的质母细胞突变损害了其区分激活配体的能力. 这种由EGFR改变的配体分离有助于癌症的发展,并可能提供新的治疗点.

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